Scientific Articles
Scientific Related Articles
The Use of Electrotherapeutics in Ophthalmology – Click Here
Regenerating Eye Tissues to Preserve and Restore Vision – Click Here
Short review of Microcurrent Stimulation in the Treatment of Ocular
Disease and a Case Presentation of 3 Stargardt’s Degeneration Siblings
Treated with Transpalpebral Microcurrent Stimulation – Click Here
Electrical Stimulation as a Means for Improving Vision – Click Here
Randomized Controlled Trial of Electro-stimulation Therapies to Modulate Retinal Blood Flow and Visual Function in Retinitis Pigmentosa – Click Here
Transpalpebral Electrical Stimulation as a Novel Therapeutic Approach to Decrease Intraocular Pressure for Open-Angle Glaucoma: A Pilot Study – Click Here
The Efficacy of Transcorneal Electrical Stimulation for the Treatment of Primary Open-angle Glaucoma: A Pilot Study. – Click Here
Clinical Trial to Evaluate Safety and Efficacy of Transdermal Electrical Stimulation on Visual Functions of Patients with Retinitis Pigmentosa – Click Here
Transcorneal electrical stimulation for retinitis pigmentosa – IQWiG
Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss
Retina World Congress – Downloadable
> Our patented microcurrent signal causes tissues to release SDF-1 the universal stem cell homing signal (investigational use only).
> Working with our partner in Florida, Bioheart, Inc. (founded by Leonhardt Ventures 1999), we are able to harvest stem cells from fat tissue at the clinic with a kit OR back in their GLP certified lab –http://www.bioheartinc.com/assets/press/FDAregistration.pdf – in Sunrise, Florida with expansion of quantity by cell culturing (investigational use only – training courses are available) – EyeCell is developing a series of clinical trials for utllizing of stem cells and endothelial progenitor cells combined with microcurrent stimulation for the treatment eye diseases such as wet and dry macular degeneration and seeks co-investigators and researchers to join us.
Stem cell trial sets sight on blindness
Transcorneal electrical stimulation rescues axotomized retinal … – NCBI
www.ncbi.nlm.nih.gov/pubmed/15914636
by T Morimoto – 2005 – Cited by 108 – Related articles
Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF–1 system. Morimoto T(1), Miyoshi T, Matsuda …
Electrical stimulation modulates IGF binding protein transcript levels in …
www.ncbi.nlm.nih.gov/pubmed/15584093
by S Bayol – 2005 – Cited by 20 – Related articles
Cell Biochem Funct. 2005 Sep-Oct;23(5):361-5. Electrical stimulation modulates IGF binding protein transcript levels in C2C12 myotubes. Bayol S(1), Brownson …
Effect of electrical stimulation on IGF-1 transcription by L … – Springer
link.springer.com/article/10.1007%2Fs10384-008-0533-y
by T Sato – 2008 – Cited by 29 – Related articles
Jul 27, 2008 – To investigate the effect of electrical stimulation (ES) on the induction of insulin-like growth factor 1 (IGF–1) in cultured retinal Müller cells.
IGF-1 Controlled Release by Bioelectric Stimulation Provisional Patent …
mysocialgoodnews.com/igf–1-controlled-release-bioelectric–stimulation-provisional-p…
Apr 2, 2016 – social entrepreneurship, impact investing, philanthropy … The startups via LeonhardtVentures have filed a provisional patent application with … Dr. Genovese has been conductingelectrical stimulation based regeneration …. Provisional Patent Application | My Social Good News on Howard Leonhardt to .
SDF-1 STEM CELL HOMING PROPERTIES
Low current electrical stimulation upregulates cytokine expression in …
www.ncbi.nlm.nih.gov/…/22006493
National Center for Biotechnology Information
by L Salcedo – 2012 – Cited by 4 – Related articles
Oct 18, 2011 – Low current electrical stimulation upregulates cytokine expression in the … After 1-h stimulation and euthanasia 24 h after, SDF–1 and MCP-3 …
SDF-1 Effect on Hematopoietic Progenitor and Stem Cell Mobilization …
https://www.rndsystems.com/…/sdf–1-effect-hematopoietic-progenitor-a…
R&D Systems
SDF–1 plays a key role in providing these directional cues, orchestrating CD34+ cell migration andhoming from the fetal liver into the BM.4,6-8 Both SDF–19 and …
How do stem cells find their way home? | Blood Journal
www.bloodjournal.org/content/106/6/1901
by T Lapidot – 2005 – Cited by 894 – Related articles
Homing is thought to be a coordinated, multistep process, which involves signaling by stromal-derived factor 1 (SDF–1) and stem cell factor (SCF), activation of …
SDF-1 EYE REGENERATION PROPERTIES
Stromal Cell-Derived Factor-1 Is Essential for Photoreceptor …
National Center for Biotechnology Information
by H Otsuka – 2010 – Cited by 23 – Related articles
SDF–1 blockade with a neutralizing antibody increased photoreceptor cell loss and … cells to neovascularization andregeneration sites in heart, liver,, and eye., … In some eyes, immediately after RD induction, 1 μg anti-SDF-1α antibody ..
CXCL12/SDF-1 facilitates optic nerve regeneration. – NCBI
National Center for Biotechnology Information
by A Heskamp – 2013 – Cited by 16 – Related articles
Neurobiol Dis. 2013 Jul;55:76-86. doi: 10.1016/j.nbd.2013.04.001. Epub 2013 Apr 8. CXCL12/SDF–1facilitates optic nerve regeneration. Heskamp A(1) .
IGF-1
Induction of retinal regeneration in vivo by growth factors. – NCBI
www.ncbi.nlm.nih.gov/pubmed/1936569 National Center for Biotechnology Information
by CM Park – 1991 – Cited by 115 – Related articles
Induction of retinal regeneration in vivo by growth factors. … Polymer implants containing bFGF were inserted into eyes of chicken embryos immediately … factor-beta, transforming growth factor-beta 1,insulin, or insulin–like growth factors I or II.
Effect of insulin-like growth factor-1 on corneal surface ultrastructure …
www.ncbi.nlm.nih.gov/…/24211688 National Center for Biotechnology Information
by C Wang – 2014 – Cited by 4 – Related articles
Nov 7, 2013 – Effect of insulin–like growth factor-1 on corneal surface ultrastructure and nerve regeneration of rabbit eyes after laser in situ keratomileusis. … IGF-1 can effectively accelerate the earlyrepair of corneal surface ultrastructure …
Norrin mediates angiogenic properties via the induction of insulin-like …
www.ncbi.nlm.nih.gov/…/26706283
National Center for Biotechnology Information
by LF Zeilbeck – 2015 – Related articles
Dec 17, 2015 – (2)Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, … Moreover, Norrin induces vascular repair following an … Since insulin–like growth factor (IGF)-1 is a very potent angiogenic molecule, …
HGF
Hepatocyte Growth Factor Promotes Long‐Term Survival …
https://www.deepdyve.com/…/hepatocyte–growth–factor-promotes-long-t…
Jun 4, 2014 – Read “Hepatocyte Growth Factor Promotes Long‐Term Survival and … Axonal Regeneration of Retinal Ganglion Cells after Optic Nerve … eye was performed either immediately after injury or delayed until 7 days post-injury.
FOLLISTATIN
Tissue absence initiates regeneration through Follistatin …
elifesciences.org/content/2/e00247
eLife
by MA Gaviño – 2013 – Cited by 16 – Related articles
Sep 10, 2013 – Tissue absence initiates regeneration throughFollistatin-mediated inhibition of … (D) fst(RNAi) animals lackedeye progenitors following head …
EYE REGENERATION GENERAL
An Eye on Regeneration – NCBI – National Institutes of Health
National Center for Biotechnology Information
by MK Call – 2005 – Cited by 11 – Related articles
Lens regeneration in newts is a remarkable process, whereby a lost tissue is replaced by transdifferentiation of adult tissues that only a few organisms possess.
Regenerating Lost Vision in Glaucoma | Glaucoma …
www.glaucoma.org/…/regenerating-lost-…
Glaucoma Research Foundation
Feb 10, 2016 – When we catch glaucoma early enough, we are fortunate in much of the developed world to be able to lower eyepressure with medicine or …
How fish can regenerate eye injuries at the cellular level — ScienceDaily
https://www.sciencedaily.com/releases/2016/05/160506100241.htm
Science Daily
May 6, 2016 – Scientists have examined the key function in the process of regeneration in the eyes of fish. Surprisingly, a single genetic factor triggers two …
Drug ‘cocktail’ could restore vision in optic nerve injury – Vector
vector.childrenshospital.org/…/drug-cocktail-could-restore-vision-in-optic-nerve-injur…
Jan 14, 2016 – Gene therapy achieved extensive optic nerve regeneration, … key growth factors(osteopontin, insulin–like growth factor 1 and ciliary neurotrophic factor. … But the axons weren’t able to carry signals all the way from the eye to …
VEGF and eNOS
VEGF-B can regenerate damaged peripheral nerves without …
www.news-medical.net/…/VEGF-B-can-regenerate-damaged-peripheral-…
Nov 18, 2014 – But if VEGF-B was delivered to the corneas of these mice, nerve regeneration improved. The new nerves restored normal sensation to the eye, …
Growth factor regenerates damaged nerves without …
https://news.uic.edu/growth-factor-regen…
University of Illinois at Chicago
Nov 17, 2014 – VEGF-A is a factor that Rosenblatt and several others have studied … But if VEGF-B was delivered to the corneas of these mice, nerve regeneration improved. The new nerves restored normal sensation to the eye, and proper …
Endogenous VEGF Is Required for Visual Function …
journals.plos.org/plosone/article?id=10.1371/journal.pone.0003554
by M Saint-Geniez – 2008 – Cited by 332 – Related articles
Nov 3, 2008 – To examine VEGF expression patterns in adulteye, we used mice …… of retinal ganglion cell development, survival, and regeneration.
ACTIVIN A+B
Neural Regeneration and Cell Replacement: a view from the eye – NCBI
www.ncbi.nlm.nih.gov/…/PMC26922…
National Center for Biotechnology Information
by D Lamba – 2008 – Cited by 119 – Related articles
Jun 5, 2008 – Studies of eye regeneration have a long history, dating back to the … B. The retina first becomes recognizable at the optic vesicle stage of development. …. stimulate regeneration (Spence et al., 2007), while activin signaling …
STEM CELLS
Stem cells in retinal regeneration: past, present and future
National Center for Biotechnology Information
by CM Ramsden – 2013 – Cited by 101 – Related articles
Retinal disease candidates for stem cell-based regeneration … The eye is easily accessible and there is a wealth of surgical expertise in dealing with the …. In the case of wet AMD, intravitreal injection of anti–VEGF agents can stabilise the …
Stem cells regenerate human lens after cataract surgery, restoring …
https://www.sciencedaily.com/releases/2016/03/160309135653.htm
Science Daily
Mar 9, 2016 – In the case of the human eye, lens epithelial stem cells or LECs generate replacementlens cells throughout a person’s life, though production …
A blind woman has regained sight following a controversial stem cell …
www.sciencealert.com/a-blind-woman-has-regained-sight-thanks-to-a-controversial-st…
Feb 29, 2016 – The doctor who performed the stem cell treatment, ophthalmologist Jeffrey … a case study on Belton in the journal Neural Regeneration Research. … stem cells were injected into her righteye’s retina and left eye’s optic nerve?
MICRO PUMP
Implanted Ophthalmic Micropump – Enhanced Vision
https://www.enhancedvision.com/…vision…/implanted-ophthalmic-micro…
Anyone who gets frequent eye injections for wet AMD or diabetic macular edema would be quick to agree that if there was a treatment that made it possible to …
BioElectric and Microcurrent Stimulation
Microcurrent Stimulation | Ophthamologist – Eye Diseases …
www.healingtheeye.com/microcurrent.html
Many patients become interested in microcurrent after reading my book Microcurrent Stimulation: Miracle Eye Cure and they expect to experience the same type …
Search Results
[PDF]
Electrical Stimulation to Enhance Axonal Regeneration after … – Utah
content.lib.utah.edu/utils/getfile/collection/ehsl-nam/id/1201/filename/image
Introduction: The inability of CNS axons to regenerate after injury is attributable both to … Electrical stimulation of the optic nerve elevates cAMP levels … inhibitor isobutyl methylxanthine was injected into a subset of these eyes post-stimulation.
Axonal regeneration induced by repetitive electrical stimulation of …
www.ncbi.nlm.nih.gov/…/19484445
National Center for Biotechnology Information
by Y Tagami – 2009 – Cited by 33 – Related articles
May 31, 2009 – Axonal regeneration induced by repetitive electrical stimulation of … from a corneal contact lens electrode, was used to stimulate the eye.
Therapeutic Electrical Stimulation helps to improve vision without …
https://www.restore-vision.com/new-therapy-restore-vision/
Impaired or poor vision can be improved or stabilized within few weeks by using non invasive therapeutic electrical stimulation.
First-ever restoration of vision achieved in mice | News Center …
Jul 11, 2016 – In experiments in mice described in a study published online July 11 in Nature Neuroscience, the scientists coaxed optic-nerve cables, responsible for conveying visual information from the eye to the brain, into regenerating after they had been completely severed, and found that they could retrace their …
Endogenous bioelectric currents promote differentiation of the …
Aug 30, 2017 – An EF also promoted the expression of β‐crystallin, aquaporin‐0 (AQP0) and the Beaded Filament Structural Protein 2 (BFSP2) in lens epithelial cells (LECs), all of which are hallmarks of differentiation. In addition, applied EF activated the AKT and CDC2 and inhibition of AKT reduced the activation of …
A Bionic Lens Undergoing Clinical Trials Could Give You Superhuman Abilities In Two Years
Transcorneal Electrical Stimulation Rescues Axotomized Retinal …
iovs.arvojournals.org/article.aspx?articleid=2163762
Transcorneal Electrical Stimulation Rescues Axotomized Retinal Ganglion Cells by Activating Endogenous Retinal IGF-1 System …. at 4°C. The supernatants were collected, and the protein concentration was determined by the Bradford protein assay with bovine serum albumin as a standard (Bio-Rad, Hercules, CA).
Eye regeneration technique lets blind mice see the light | Science …
Regenerating Eye Tissues to Preserve and Restore Vision – Cell Press
Jun 1, 2018 – studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including
Microcurrent stimulation in the treatment of dry and wet macular …
Dec 17, 2015 – There were 25 eyes with dry age-related macular degeneration (DAMD) and six eyes with wet age-related macular degeneration (WAMD).
(PDF) Microcurrent stimulation in the treatment of dry and wet macular …
Whole-eye electrical stimulation therapy preserves visual function and …
Jun 18, 2016 – Low-level electrical stimulation to the eye has been shown to be … Retinal and visualfunctions were assessed every 4 weeks using ….. synthetase (Gs), Caspase 3 (Casp3), BCL-2 associated X protein (Bax). ….. mediate the onset of and recovery from retinal injury (Barnett et al., 2000; Gorovits et al., 1997).
The Age-Regulating Protein Klotho Is Vital to Sustain Retinal Function …
Klotho mRNA and protein were detected in the wild-type mouse retina, with … mouse (∼8 weeks), no overt photoreceptor cell loss was observed, however, … The whole eye or retina was removed from deeply anesthetized mice at 3 or 7 … Use of Animals in Ophthalmic and Vision Research using protocols approved by the …
Could the Loss of an Anti-Aging Gene Contribute to Wet and Dry …
Oct 22, 2013 – The research, entitled Klotho Regulates Retinal Pigment Epithelial Functions … In wet macular degeneration, the choroid (a part of the eye containing … and receive light, resulting in a rapid and severe loss of central vision.
The Expressions of Klotho Family Genes in Human Ocular Tissues …
Purpose: Klotho genes are expressed in limited tissues and have been found to … tissues were isolated from human eyeballs collected from Henan Eye Bank.
Loss of anti-aging gene possible culprit in age-related macular …
Fourth Annual Symposium on Biologically Closed Electrical Circuits
Presented by Grace Halloran, Ph.D. to the
Fourth Annual Symposium on Biologically Closed Electrical Circuits, October 27, 1997, Sponsored by Mankato University, Minnesota
Abstract
From December 1995 to September 1997, thirty individuals diagnosed with typically untreatable eye diseases including retinitis pigmentosa, macular degeneration, CMV-retinitis, Stargardt disease
RESEARCH PAPERS
TAP Milestone II Report
Milestone II: “Identify where and how we will conduct live subject studies in which we will test the three components of EyeCell at the same time. We have already discussed this issue and have plans to conduct the studies with the help of Bryan Jones at the Moran Eye...
Microcurrent Stimulation for Macular Degeneration
Microcurrent stimulation for macular degeneration is one of many different therapies Dr. Edward Kondrot, MD. uses for his patients. Ophthalmologist and Doctor of Homeopathy 1. First tell us a little about yourself, your credentials, your practice and how you...
Macular Degeneration
Age-Related Macular Degeneration (AMD) is one of the leading causes of severe vision loss and blindness in the adult population. With more than 1.6 million existing cases and approximately 200,000 new cases each year in the U.S. Macular degeneration is an eye disorder...
Leonhardt’s Launchpads Accelerator Announces Demo Days and Showcases September in San Francisco and Palo Alto for Organ Regeneration and Recovery Focused Startups
Leonhardt's Launchpads www.leonhardtventures.com an innovation and startup accelerator focused exclusively on organ and tissue regeneration and recovery technologies announced today Demo Days and Innovation Showcases to take place in San Francisco September 26th and...
The history of resonance therapy
The history of resonance therapy