Scientific Articles

Scientific Related Articles

Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss

Retina World Congress – Downloadable

Alternating Current Stimulation for Vision Restoration after Optic Nerve Damage: A Randomized Clinical Trial 

Neurobiology of Disease

>  Our patented microcurrent signal causes tissues to release SDF-1 the universal stem cell homing signal (investigational use only).
>  Working with our partner in Florida, Bioheart, Inc. (founded by Leonhardt Ventures 1999), we are able to harvest stem cells from fat tissue at the clinic with a kit OR back in their GLP certified lab –http://www.bioheartinc.com/assets/press/FDAregistration.pdf – in Sunrise, Florida with expansion of quantity by cell culturing (investigational use only – training courses are available) –  EyeCell is developing a series of clinical trials for utllizing of stem cells and endothelial progenitor cells combined with microcurrent stimulation for the treatment eye diseases such as wet and dry macular degeneration and seeks co-investigators and researchers to join us.

Stem cell trial sets sight on blindness

Stem Cell Training Inc.

Transcorneal electrical stimulation rescues axotomized retinal … – NCBI

www.ncbi.nlm.nih.gov/pubmed/15914636

by T Morimoto – ‎2005 – ‎Cited by 108 – ‎Related articles

Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF1 system. Morimoto T(1), Miyoshi T, Matsuda …

Electrical stimulation modulates IGF binding protein transcript levels in …

www.ncbi.nlm.nih.gov/pubmed/15584093

by S Bayol – ‎2005 – ‎Cited by 20 – ‎Related articles

Cell Biochem Funct. 2005 Sep-Oct;23(5):361-5. Electrical stimulation modulates IGF binding protein transcript levels in C2C12 myotubes. Bayol S(1), Brownson …

Effect of electrical stimulation on IGF-1 transcription by L … – Springer

link.springer.com/article/10.1007%2Fs10384-008-0533-y

by T Sato – ‎2008 – ‎Cited by 29 – ‎Related articles

Jul 27, 2008 – To investigate the effect of electrical stimulation (ES) on the induction of insulin-like growth factor 1 (IGF1) in cultured retinal Müller cells.

IGF-1 Controlled Release by Bioelectric Stimulation Provisional Patent …

mysocialgoodnews.com/igf1-controlled-release-bioelectricstimulation-provisional-p…

Apr 2, 2016 – social entrepreneurship, impact investing, philanthropy … The startups via LeonhardtVentures have filed a provisional patent application with … Dr. Genovese has been conductingelectrical stimulation based regeneration …. Provisional Patent Application | My Social Good News on Howard Leonhardt to .

SDF-1 STEM CELL HOMING PROPERTIES 

Low current electrical stimulation upregulates cytokine expression in …

www.ncbi.nlm.nih.gov/…/22006493

National Center for Biotechnology Information

by L Salcedo – ‎2012 – ‎Cited by 4 – ‎Related articles

Oct 18, 2011 – Low current electrical stimulation upregulates cytokine expression in the … After 1-h stimulation and euthanasia 24 h after, SDF1 and MCP-3 …

SDF-1 Effect on Hematopoietic Progenitor and Stem Cell Mobilization …

https://www.rndsystems.com/…/sdf1-effect-hematopoietic-progenitor-a…

R&D Systems

SDF1 plays a key role in providing these directional cues, orchestrating CD34+ cell migration andhoming from the fetal liver into the BM.4,6-8 Both SDF19 and …

How do stem cells find their way home? | Blood Journal

www.bloodjournal.org/content/106/6/1901

by T Lapidot – ‎2005 – ‎Cited by 894 – ‎Related articles

Homing is thought to be a coordinated, multistep process, which involves signaling by stromal-derived factor 1 (SDF1) and stem cell factor (SCF), activation of …

SDF-1 EYE REGENERATION PROPERTIES

Stromal Cell-Derived Factor-1 Is Essential for Photoreceptor …

www.ncbi.nlm.nih.gov/ 

 

National Center for Biotechnology Information

by H Otsuka – ‎2010 – ‎Cited by 23 – ‎Related articles

SDF1 blockade with a neutralizing antibody increased photoreceptor cell loss and … cells to neovascularization andregeneration sites in heart, liver,, and eye., … In some eyes, immediately after RD induction, 1 μg anti-SDF-1α antibody ..

CXCL12/SDF-1 facilitates optic nerve regeneration. – NCBI

www.ncbi.nlm.nih.gov/ 

 

National Center for Biotechnology Information

by A Heskamp – ‎2013 – ‎Cited by 16 – ‎Related articles

Neurobiol Dis. 2013 Jul;55:76-86. doi: 10.1016/j.nbd.2013.04.001. Epub 2013 Apr 8. CXCL12/SDF1facilitates optic nerve regeneration. Heskamp A(1) .

IGF-1

Induction of retinal regeneration in vivo by growth factors. – NCBI

www.ncbi.nlm.nih.gov/pubmed/1936569 National Center for Biotechnology Information

by CM Park – ‎1991 – ‎Cited by 115 – ‎Related articles

Induction of retinal regeneration in vivo by growth factors. … Polymer implants containing bFGF were inserted into eyes of chicken embryos immediately … factor-beta, transforming growth factor-beta 1,insulin, or insulinlike growth factors I or II.

Effect of insulin-like growth factor-1 on corneal surface ultrastructure …

www.ncbi.nlm.nih.gov/…/24211688 National Center for Biotechnology Information

by C Wang – ‎2014 – ‎Cited by 4 – ‎Related articles

Nov 7, 2013 – Effect of insulinlike growth factor-1 on corneal surface ultrastructure and nerve regeneration of rabbit eyes after laser in situ keratomileusis. … IGF-1 can effectively accelerate the earlyrepair of corneal surface ultrastructure …

Norrin mediates angiogenic properties via the induction of insulin-like …

www.ncbi.nlm.nih.gov/…/26706283

National Center for Biotechnology Information

by LF Zeilbeck – ‎2015 – ‎Related articles

Dec 17, 2015 – (2)Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, … Moreover, Norrin induces vascular repair following an … Since insulinlike growth factor (IGF)-1 is a very potent angiogenic molecule, …

HGF 

Hepatocyte Growth Factor Promotes Long‐Term Survival …

https://www.deepdyve.com/…/hepatocytegrowthfactor-promotes-long-t… 

Jun 4, 2014 – Read “Hepatocyte Growth Factor Promotes Long‐Term Survival and … Axonal Regeneration of Retinal Ganglion Cells after Optic Nerve … eye was performed either immediately after injury or delayed until 7 days post-injury.

FOLLISTATIN

Tissue absence initiates regeneration through Follistatin …

elifesciences.org/content/2/e00247 

 

eLife

by MA Gaviño – ‎2013 – ‎Cited by 16 – ‎Related articles

Sep 10, 2013 – Tissue absence initiates regeneration throughFollistatin-mediated inhibition of … (D) fst(RNAi) animals lackedeye progenitors following head …

EYE REGENERATION GENERAL 

An Eye on Regeneration – NCBI – National Institutes of Health

www.ncbi.nlm.nih.gov/ 

 

National Center for Biotechnology Information

by MK Call – ‎2005 – ‎Cited by 11 – ‎Related articles

Lens regeneration in newts is a remarkable process, whereby a lost tissue is replaced by transdifferentiation of adult tissues that only a few organisms possess.

Regenerating Lost Vision in Glaucoma | Glaucoma …

www.glaucoma.org/…/regenerating-lost-… 

 

Glaucoma Research Foundation

Feb 10, 2016 – When we catch glaucoma early enough, we are fortunate in much of the developed world to be able to lower eyepressure with medicine or …

How fish can regenerate eye injuries at the cellular level — ScienceDaily

https://www.sciencedaily.com/releases/2016/05/160506100241.htm

Science Daily

May 6, 2016 – Scientists have examined the key function in the process of regeneration in the eyes of fish. Surprisingly, a single genetic factor triggers two …

Drug ‘cocktail’ could restore vision in optic nerve injury – Vector

vector.childrenshospital.org/…/drug-cocktail-could-restore-vision-in-optic-nerve-injur

Jan 14, 2016 – Gene therapy achieved extensive optic nerve regeneration, … key growth factors(osteopontin, insulinlike growth factor 1 and ciliary neurotrophic factor. … But the axons weren’t able to carry signals all the way from the eye to …

VEGF and eNOS

VEGF-B can regenerate damaged peripheral nerves without …

www.news-medical.net/…/VEGF-B-can-regenerate-damaged-peripheral-… 

Nov 18, 2014 – But if VEGF-B was delivered to the corneas of these mice, nerve regeneration improved. The new nerves restored normal sensation to the eye, …

Growth factor regenerates damaged nerves without …

https://news.uic.edu/growth-factor-regen 

 

University of Illinois at Chicago

Nov 17, 2014 – VEGF-A is a factor that Rosenblatt and several others have studied … But if VEGF-B was delivered to the corneas of these mice, nerve regeneration improved. The new nerves restored normal sensation to the eye, and proper …

Endogenous VEGF Is Required for Visual Function …

journals.plos.org/plosone/article?id=10.1371/journal.pone.0003554 

by M Saint-Geniez – ‎2008 – ‎Cited by 332 – ‎Related articles

Nov 3, 2008 – To examine VEGF expression patterns in adulteye, we used mice …… of retinal ganglion cell development, survival, and regeneration.

ACTIVIN A+B

Neural Regeneration and Cell Replacement: a view from the eye – NCBI

www.ncbi.nlm.nih.gov/…/PMC26922

National Center for Biotechnology Information

by D Lamba – ‎2008 – ‎Cited by 119 – ‎Related articles

Jun 5, 2008 – Studies of eye regeneration have a long history, dating back to the … B. The retina first becomes recognizable at the optic vesicle stage of development. …. stimulate regeneration (Spence et al., 2007), while activin signaling …

STEM CELLS 

Stem cells in retinal regeneration: past, present and future

www.ncbi.nlm.nih.gov/ 

 

National Center for Biotechnology Information

by CM Ramsden – ‎2013 – ‎Cited by 101 – ‎Related articles

Retinal disease candidates for stem cell-based regeneration … The eye is easily accessible and there is a wealth of surgical expertise in dealing with the …. In the case of wet AMD, intravitreal injection of antiVEGF agents can stabilise the …

Stem cells regenerate human lens after cataract surgery, restoring …

https://www.sciencedaily.com/releases/2016/03/160309135653.htm

Science Daily

Mar 9, 2016 – In the case of the human eyelens epithelial stem cells or LECs generate replacementlens cells throughout a person’s life, though production …

A blind woman has regained sight following a controversial stem cell …

www.sciencealert.com/a-blind-woman-has-regained-sight-thanks-to-a-controversial-st

Feb 29, 2016 – The doctor who performed the stem cell treatment, ophthalmologist Jeffrey … a case study on Belton in the journal Neural Regeneration Research. … stem cells were injected into her righteye’s retina and left eye’s optic nerve?

MICRO PUMP 

Implanted Ophthalmic Micropump – Enhanced Vision

https://www.enhancedvision.com/…vision…/implanted-ophthalmic-micro 

Anyone who gets frequent eye injections for wet AMD or diabetic macular edema would be quick to agree that if there was a treatment that made it possible to …

BioElectric and Microcurrent Stimulation 

Microcurrent Stimulation | Ophthamologist – Eye Diseases …

www.healingtheeye.com/microcurrent.html 

Many patients become interested in microcurrent after reading my book Microcurrent Stimulation: Miracle Eye Cure and they expect to experience the same type …

Search Results

[PDF]

Electrical Stimulation to Enhance Axonal Regeneration after … – Utah

content.lib.utah.edu/utils/getfile/collection/ehsl-nam/id/1201/filename/image

Introduction: The inability of CNS axons to regenerate after injury is attributable both to … Electrical stimulation of the optic nerve elevates cAMP levels … inhibitor isobutyl methylxanthine was injected into a subset of these eyes post-stimulation.

Axonal regeneration induced by repetitive electrical stimulation of …

www.ncbi.nlm.nih.gov/…/19484445

National Center for Biotechnology Information

by Y Tagami – ‎2009 – ‎Cited by 33 – ‎Related articles

May 31, 2009 – Axonal regeneration induced by repetitive electrical stimulation of … from a corneal contact lens electrode, was used to stimulate the eye.

Therapeutic Electrical Stimulation helps to improve vision without …

https://www.restore-vision.com/new-therapy-restore-vision/

Impaired or poor vision can be improved or stabilized within few weeks by using non invasive therapeutic electrical stimulation.

First-ever restoration of vision achieved in mice | News Center …

Jul 11, 2016 – In experiments in mice described in a study published online July 11 in Nature Neuroscience, the scientists coaxed optic-nerve cables, responsible for conveying visual information from the eye to the brain, into regenerating after they had been completely severed, and found that they could retrace their …

Endogenous bioelectric currents promote differentiation of the …

by L Cao – ‎2018

Aug 30, 2017 – An EF also promoted the expression of β‐crystallin, aquaporin‐0 (AQP0) and the Beaded Filament Structural Protein 2 (BFSP2) in lens epithelial cells (LECs), all of which are hallmarks of differentiation. In addition, applied EF activated the AKT and CDC2 and inhibition of AKT reduced the activation of …

A Bionic Lens Undergoing Clinical Trials Could Give You Superhuman Abilities In Two Years

Transcorneal Electrical Stimulation Rescues Axotomized Retinal …

iovs.arvojournals.org/article.aspx?articleid=2163762

 

by T Morimoto – ‎2005 – ‎Cited by 132 – ‎Related articles

Transcorneal Electrical Stimulation Rescues Axotomized Retinal Ganglion Cells by Activating Endogenous Retinal IGF-1 System …. at 4°C. The supernatants were collected, and the protein concentration was determined by the Bradford protein assay with bovine serum albumin as a standard (Bio-Rad, Hercules, CA).

Eye regeneration technique lets blind mice see the light | Science …

www.sciencemag.org/news/2018/…/eye-regeneration-technique-lets-blind-mice-see-li…

Regenerating Eye Tissues to Preserve and Restore Vision – Cell Press

 

https://www.cell.com/cell-stem-cell/pdf/S1934-5909(18)30231-5.pdf
by JH Stern – ‎2018 – ‎Cited by 2 – ‎Related articles

Jun 1, 2018 – studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including

Microcurrent stimulation in the treatment of dry and wet macular …

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689270/

 

by L Chaikin – ‎2015 – ‎Cited by 6 – ‎Related articles

Dec 17, 2015 – There were 25 eyes with dry age-related macular degeneration (DAMD) and six eyes with wet age-related macular degeneration (WAMD).

Abstract · ‎Introduction · ‎Methods · ‎Results

(PDF) Microcurrent stimulation in the treatment of dry and wet macular …

 

https://www.researchgate.net/…/288836543_Microcurrent_stimulation_in_the_treatment…
Jul 31, 2018 – There were 25 eyes with dry age-related macular degeneration (DAMD) and six eyes with wet age-related macular degeneration (WAMD).

Whole-eye electrical stimulation therapy preserves visual function and …


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985439/
by AM Hanif – ‎2016 – ‎Cited by 6 – ‎Related articles

Jun 18, 2016 – Low-level electrical stimulation to the eye has been shown to be … Retinal and visualfunctions were assessed every 4 weeks using ….. synthetase (Gs), Caspase 3 (Casp3), BCL-2 associated X protein (Bax). ….. mediate the onset of and recovery from retinal injury (Barnett et al., 2000; Gorovits et al., 1997).

The Age-Regulating Protein Klotho Is Vital to Sustain Retinal Function …


https://iovs.arvojournals.org/article.aspx?articleid=2202958

by NJ Reish – ‎2013 – ‎Cited by 9 – ‎Related articles

Klotho mRNA and protein were detected in the wild-type mouse retina, with … mouse (∼8 weeks), no overt photoreceptor cell loss was observed, however, … The whole eye or retina was removed from deeply anesthetized mice at 3 or 7 … Use of Animals in Ophthalmic and Vision Research using protocols approved by the …

 

Could the Loss of an Anti-Aging Gene Contribute to Wet and Dry …


https://www.visionaware.org/blog/visionaware-blog/could-the-loss-of…/12

Oct 22, 2013 – The research, entitled Klotho Regulates Retinal Pigment Epithelial Functions … In wet macular degeneration, the choroid (a part of the eye containing … and receive light, resulting in a rapid and severe loss of central vision.

The Expressions of Klotho Family Genes in Human Ocular Tissues …


https://www.tandfonline.com/doi/abs/10.1080/02713683.2016.1259421
by Y Zhang – ‎2017 – ‎Cited by 4 – ‎Related articles

Purpose: Klotho genes are expressed in limited tissues and have been found to … tissues were isolated from human eyeballs collected from Henan Eye Bank.

Loss of anti-aging gene possible culprit in age-related macular …


https://www.sciencedaily.com/releases/2013/10/131008182343.htm

Oct 8, 2013 – They say that in their animal studies, loss of Klotho expression leads to … important role in inhibiting the overgrowth of blood vessels in the eye, a major … the leading causes of irreversible vision loss and blindness worldwide.
Fourth Annual Symposium on Biologically Closed Electrical Circuits

Presented by Grace Halloran, Ph.D. to the

Fourth Annual Symposium on Biologically Closed Electrical Circuits, October 27, 1997, Sponsored by Mankato University, Minnesota

Abstract

From December 1995 to September 1997, thirty individuals diagnosed with typically untreatable eye diseases including retinitis pigmentosa, macular degeneration, CMV-retinitis, Stargardt disease and others attended an integrated treatment protocol employing bioelectrical stimulation, nutritional and herbal supplementation (including Ginkgo Biloba, Lutein, DHA) and other health care modalities. The study was monitored by a neuro-opthalmologist, evaluating standard clinical visual function examinations, including objective field of vision tests obtained by the Humphrey FOV analyzer, visual acuity and color discrimination. Four controls were evaluated, with the monitors masked, and although the sample was small, the results were significant in their lack of change.

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